Comment by blackeyeblitzar
Comment by blackeyeblitzar 4 days ago
That depends. A lot of people experience significant GI issues. And it isn’t clear yet if those issues are reversible after stopping. It’s still best for people to naturally control their weight and diet. Is one better than the other - depends on how overweight and how severe the side effects. Right now I feel like there isn’t much focus and rigorous study of those side effects but over time I expect it will reduce the overall positives of the drug somewhat.
"A lot of people experience significant GI issues. And it isn’t clear yet if those issues are reversible after stopping."
I don't think there's any reasonable definition of "a lot" where this is true. A significant number of people experience GI issues. Most of them subside after a time. There is some evidence that a small number of people may experience more severe GI issues that don't go away after stopping.
"It’s still best for people to naturally control their weight and diet."
What is your evidence for this? Right now, it's looking like the "unnatural" GLP-1 agonists are racking up quite a score against "natural" methods like "willpower" and programmed diets. It's not a useful distinction, in any case. These medications cause reduced calorie consumption, and reduced calorie consumption causes weight loss naturally.