Comment by Trasmatta
But also be careful about taking too much choline. There's lots of anecdotal reports of people taking too much choline supplements and becoming massively depressed.
But also be careful about taking too much choline. There's lots of anecdotal reports of people taking too much choline supplements and becoming massively depressed.
The other problem with supplementing with too much choline may be elevated TMAO:
"Dietary Choline Supplements, but Not Eggs, Raise Fasting TMAO Levels in Participants with Normal Renal Function: A Randomized Clinical Trial"
It helps to mention what TMAO is:
> Choline is a dietary precursor to the gut microbial generation of the pro-thrombotic and pro-atherogenic metabolite trimethylamine-N-oxide (TMAO).
Interestingly many antidepressants are anticholinergic (as are many nootropes, so you have to be super careful mixing to the two).