Sure, but almost no one is managing their own keys and knows enough about the various e2ee algorithms to make these decisions on their own.
Do you know of a good piece of software or tool that lets a layperson interface with any cloud storage provider?
The closest I've found is VeraCrypt, which is near the edge of what I'd call layperson-friendly. But if you store a VeraCrypt drive on the cloud, you'll need to re-upload the entire encrypted file--usually quite large--every time you change anything at all. That's a _lot_ of bandwidth, and likely to be quite slow to sync.
https://github.com/restic/restic
not exactly for a "layperson", to be honest, but easy enough for someone familiar with a command line
https://cryptomator.org/