Comment by bitmasher9

Comment by bitmasher9 16 hours ago

2 replies

Was it ever really a debate? There’s tons of experimental evidence that shows calorie reduction leads to weight loss, even without pharmaceuticals. The Ozempic data can be explained simply by this factor. There doesn’t seem to be enough data fluctuation between the two sets to indicate a significant set of unknown variables impacting the data.

parpfish 15 hours ago

yeah, but do ozempic et al only rely on calorie reduction? i find it hard to believe that hormones only affect one thing in isolation. it may be doing something like a) suppressing appetite to reduce caloric intake AND b) shielding against a lowered metabolism due to calorie restriction.

  • tonymet 13 hours ago

    If there is predominant evidence of significant calorie reduction leading to weight loss, and no evidence of the metabolic hypothesis , what should be our conclusion?