Comment by parpfish
yeah, but do ozempic et al only rely on calorie reduction? i find it hard to believe that hormones only affect one thing in isolation. it may be doing something like a) suppressing appetite to reduce caloric intake AND b) shielding against a lowered metabolism due to calorie restriction.
If there is predominant evidence of significant calorie reduction leading to weight loss, and no evidence of the metabolic hypothesis , what should be our conclusion?