Comment by jodrellblank

You're replying as if I said that drugs can't change neurochemistry and can't change mood or behaviour, and genetics doesn't exist and can't explain anything. I wrote quite a lot because I wanted to make it pretty clear that I wasn't saying either of those things.

If your old fashioned TV glitches and you hit it and it works, that doesn't mean it had a percussive imbalance. If you sledgehammer your brain chemistry that can change your mood and behaviour, and that doesn't mean you had a chemical imbalance and need a sledgehammer every week forever. It's the lack of supported good explanation that I'm against, especially after becoming convinced that a lot (not all) depressions and anxieties are addressable with therapy - but not just any therapy with any technique, just like a TV problem can be traced to a bad solder joint or a loose wire or a warped chassis shorting out a wire, but not by just randomly poking wires and replacing components without any training or experience and saying "I tried everything so it must need hitting". Similarly, "genetics" can be a fine explanation which is why I edited Downes Syndrome into my comment, also blue eyes, Trisomy 21, Huntington's Disease, and many others.

> "As someone who, as an armature geneticist, helped design a genetic study for Stanford, can I say that I put more energy into thinking about these things over the last 45 years than you can even imagine?"

And how do you feel about these quotes I just found on Reddit: "I think my genetics are stopping me from losing weight. I am 25F 5'2 and 145lbs and I have been having the hardest time trying to lose 20 lbs; or "I hate my genetics. I'm lifting 5~6 days a week since october last year, what means almost 10 months of consistent training, but my measureaments and bodyshape still like shit" or "Are my genetics/health screwing me over or am I just shit? r/GuitarQuestions"

Do you think those uses of 'genetics' are good explanations, that the poster should be satisfied with? Explanations that have good predictive power and a clear model of finding other people with the same problem, and suggest what to do next to compensate? Or are they (as I grumble) bad explanations which don't have any predictive power because they don't specify any particular gene or its effects, in much the same way that saying "it's fate"?

> "your solution are just as bad as the ones your are prescribing."

My solution of fix the TV electronics is just as bad as "hit the TV and accept a bad explanation for how that helped"?