Comment by js2

Full paper:

https://www.nature.com/articles/s41467-026-68303-9

I was curious what the implementation looked like:

> In the short-term intervention study, participants assigned to the oat group (OG) consumed three oat meals daily for two days instead of their habitual Western diet. Each oat meal comprised 100 × g of rolled oat flakes (Demeterhof Schwab GmbH & Co. KG, Windsbach, Germany) boiled in water. To ascertain potential long-term effects, the two-day intervention period was followed by a six-week follow-up period during which the participants returned to their habitual diet without oats. Subjects assigned to the control group (CG) consumed three standardized control meals without oats on each intervention day, which were macronutrient-adapted to the OG, instead of their habitual Western diet.

> In the six-week intervention study, participants in the oat group (OG6w) replaced one habitual meal per day with an oatmeal comprising 80 × g of rolled oat flakes (Demeterhof Schwab GmbH & Co. KG), while maintaining their habitual Western diet. Participants in the corresponding control group (CG6w) maintained their habitual Western diet and remained abstinent from oats during the six-week study period according to the inclusion criteria.

This is pretty remarkable:

> Since cholesterol levels tended to remain below baseline during the six-week, oat-free follow-up period, persistent effects on lipid metabolism might be assumed (Fig. 3d). This assumption is further supported by the high compliance observed during the follow-up period, as all participants abstained from oat consumption and returned to their habitual Western diet, with no significant differences compared to their pre-study dietary patterns (Supplementary Data 2). Thus, our results indicate clearly that a high-dose oat diet improves lipid metabolism by decreasing serum TC and LDL-C levels, even after two days, which is consistent with the known cholesterol-lowering effect of oats. In addition, beneficial effects on anthropometrics and glucose metabolism were observed within each diet group (Supplementary Data 2), which we attribute to the diet-related calorie restriction.

I gotta say though, 100 grams of oats (three times a day) is a lot. That's over a cup (dry). A typical serving is less than half that (40 grams dry).