Comment by Qem

Comment by Qem 2 days ago

7 replies

So it appears oat fibers are just quite effective natural bile acid sequestrants[1]. That makes me wonder why don't we use this class of locally-acting compounds as first line cholesterol lowering treatment, instead going straight for the "bazooka" of systemic acting statins that have lots of side-effects, even affecting personality[2].

[1] https://en.wikipedia.org/wiki/Bile_acid_sequestrant

[2] https://www.bbc.com/future/article/20200108-the-medications-...

bschwarz 2 days ago

Patient compliance is notoriously fickle, especially when it comes to changing one's lifestyle (diet).

  • Qem 2 days ago

    Synthetic, stronger versions are available, as cholestyramine, colestipol or colesevalam, that can be taken as medicines, instead of demanding large changes to diet.

KempyKolibri 2 days ago

Because medication is more effective. Side effects from statins are relatively uncommon and generally mild, so it wouldn’t be ethical to use lifestyle as a first-line treatment in place of, say, a combination of low dose statin and pcsk9 inhibitors.

However many clinicians do take a “let’s sort out the problem as quickly as possible with medication, and if you want to try lifestyle and back off (or even stop entirely) the meds and see how your cholesterol is afterwards, we can do that.”

This seems like a good balance to me.

  • ViktorRay 15 hours ago

    Wait isn’t this the other way around?

    In reality lifestyle modifications are more conservative than using a medication so lifestyle modification would be first line from an ethical perspective.

    In reality though it does seem like statins are used first line by many clinicians. But ethically speaking conservative interventions like lifestyle modification in terms of changing diet and exercise should be used prior to medicating a young otherwise healthy person.

    In other groups such as when someone has had a recent heart attack of course the thought process is different. Such people should be immediately placed on a statin.

lithocarpus 2 days ago

My guess is something like, because there aren't patents on food.

There's no financial incentive for the healthcare industry to promote a healthy lifestyle.

  • sn9 2 days ago

    Doctors and public health organizations literally have dietary and physical activity guidelines.

    • lithocarpus 19 hours ago

      True, it is more complicated.

      For one, there could be some financial incentives mixed in in that health insurance companies would want their people to be healthier so they don't pay out as much, but it's not that simple for them either - the health industry as a whole profits more if there is more treatment ergo more health problems. If health care was cheap or less needed the insurers themselves would make less.

      More importantly, there can be other than financial incentives mixed in for doctors and public health organizations to encourage health. Doctors for example take an oath and I think often genuinely want their people to be healthy. Public health organizations may be more murky but there's definitely a financial and otherwise incentive for the government itself minus those corrupted by the health industry, to want people to have less health problems.