Comment by cujo1234

In addition to the reasons already mentioned (natural difficulties in translating results from animal models to humans), even attempting to achieve the same results in vitro and in animal models is complicated. They estimated that the reproducibility of these studies is approximately 50%. See Errington, T. M., Mathur, M., Soderberg, C. K., Denis, A., Perfito, N., Iorns, E., & Nosek, B. A. (2021). Investigating the replicability of preclinical cancer biology. elife, 10, e71601. https://doi.org/10.7554/eLife.71601