Comment by pixl97
>A good rule of thumb in biology and particular any kind of hormone production and balance is "use it or lose it" -
Very basic and very often wrong rule, so take it with a grain of salt.
Insulin for example is the opposite. "lose it then use it" would be a general rule for type 2 diabetics where insulin resistance commonly due to weight gain is the primary problem. Losing the weight leads to better uptake and usage. For a type 1 "lose it then use it" you typically lose the ability to produce insulin to an an autoimmune disorder, then are stuck using insulin for the rest of your life.
The body itself typically attempts to main homeostasis, but at population scales this is something that is going to have a massive range of ways it shows up. Evolution, at grand scales, doesn't care if you survive as long as enough of your population survives and breeds. At the end of the day you might just be one of those people that was born broken and to work properly you need replacement parts/chemicals. A working medical system should be there to figure out which case is which.
> Insulin for example is the opposite.
You're describing entirely orthogonal issues. In case of insulin resistance, your natural production is running full blast with demand exceeding supply because the consumer stopped caring about the hormone. In case of autoimmune disease, the natural production was killed - you can neither use nor lose what is already dead, and even if some capacity was left it will either soon be killed or atrophy under external insulin, but it will not be mourned.
So no I would say it is exactly the same - "use it or lose it" - but that does not mean that there is never a reason to manually overrule your body's attempt at homeostasis through direct manipulation. It just means that there is a very significant consequence to the process.
> The body itself typically attempts to main homeostasis, but at population scales this is something that is going to have a massive range of ways it shows up.
As a somewhat sidenote, this is also why I dislike the idea of trying to classify people into "normal" and "divergent/atypical". In my eyes we're all normal people and an entirely normal aspect of being a human is that we all differ and have individually specific needs by virtue of being built by a trillion micro-meter sized workers, each with their own hand-copied version of the blueprint, only caring about the millimeter of you in their immediate vincinity and not really talking to any of the others.