Comment by mitkebes
Basically all games work, except some multiplayer games with kernel anticheat. You can look up the status of games here:
And specifically the state of multiplayer games with anticheat here (which is a much less favorable % of working games):
https://areweanticheatyet.com/
I personally wouldn't install any kernel anticheat on a computer that I intend to use for anything important, so I would personally refuse to install the incompatible games even if I was using windows.
Take ProtonDB with a grain of salt, Apex Legends still has a Silver rating ("Runs with minor issues") despite being 100% unplayable on Linux for over a year now.