Comment by gmueckl
I remember running into issues with link-style clickable text in some parts of the UI that was almost unidentifiable as clickable because it stood alone with no similar text in non-link style nearby for reference.
There were other issues that I clearly remember. There was some remarkable jank when moving the mouse cursor across screen borders in a multi-monitor setup. If you were moving towards the edge of the current screen, Windows would under certain circumstances trap the cursor there instead of moving it across the border. I believe this was done to give "hot corners" a bigger mouse target, but that feature was almost completely DoA on desktop.