Comment by zdragnar
I honestly think the single file thing is best reserved for C, given how bad the language support for modularity is.
I've had the inverse experience dealing with a many thousand line "core.php" file way back in the day helping debug an expressionengine site (back in the php 5.2ish days) and it was awful.
Unless you have an editor which can create short links in a hierarchical tree from semantic comments to let you organize your thoughts, digging through thousands of lines of code all in the same scope can be exceptionally painful.
C has no problems splitting programs in N files, to be honest.
The reason FB (and myself, for what it is worth) often write single file large programs (Redis was split after N years of being a single file) is because with enough programming experience you know one very simple thing: complexity is not about how many files you have, but about the internal structure and conceptually separated modules boundaries.
At some point you mainly split for compilation time and to better orient yourself into the file, instead of having to seek a very large mega-file. Pointing the finger to some program that is well written because it's a single file, strlongly correlates to being not a very expert programmer.