Comment by dghlsakjg

My bellybutton fluff, uninformed opinion is that heat cycling and effective cooling are probably a much more limiting factor.

If you are running a gpu at 60C for months at a time, but never idling it (crypto use case), I would actually hazard a guess that it is better than cycling it with intermittent workloads due to thermal expansion.

That of course presupposes effective, consistent cooling.