Comment by HarHarVeryFunny

There is a video below of mysterymath presenting LLVM-MOS where he talks about reserving 32 bytes of zero page to present to LLVM as 16 16-bit registers, to be able to utilize it's register allocator, which does seem a sane approach.

https://www.youtube.com/watch?v=ejbTKtgSZI0

However his github doesn't show any activity on it in the last 2 years.

https://github.com/mysterymath/llvm-mos