If you can figure out a way to apply thrust that doesn't require you to lug mass with you and throw it out the back of your spacecraft you will open up the stars to exploration. If not the rocket equation will wreck your plans every time.
75k years of reliable operation for complex machines operating in a hostile environment is a different story. This includes organic life. You can't just bottle everything up and wake up thousands of years in the future, you will be under constant bombardment by high energy particles, micrometeorites, and the relentless cold vacuum of space with no access to new raw material or energy for almost the entire trip.
If you can make that kind of trip the question becomes why bother? You could have used the same technology (actually a much easier version of the tech since you will have access to external resources and don't need to attach enormous engines to get it moving and then stopping at the destination) to use the almost unlimited space in your home solar system instead.
Unless your sun is literally about to explode it is hard to make the argument for the incredibly difficult and long journey to a neighboring solar system.
>If you can figure out a way to apply thrust that doesn't require you to lug mass with you and throw it out the back of your spacecraft you will open up the stars to exploration
This is also called "Everything we know about physics is so radically wrong that it shouldn't be possible for us to make the predictions we do"
Reactionless drives are not physical, or if they are physically possible, will have such unique quirks and constraints as to be meaningless outside of some insane laboratory setup.
For example, making very high weight new atoms that have never existed in the universe before is physically possible, but the realities of making those atoms and their nuclear instability means it doesn't matter even if a super heavy element has some crazy properties that we would like to exploit, because there will never be enough of that element to make anything out of. The "rules" of atoms should still work well above 180 protons, but other physics makes that meaningless.
Without reactionless drives, interstellar travel is so physically difficult to be essentially impossible, and no amount of engineering or cleverness can change that.