Comment by doublerabbit

Apologies if you've already ruled this out, but hand pain is very often caused by strain/injury from further up the arms, the shoulders, or even the neck. You may find that pulling your shoulders back or relaxing them, or adjusting your arm posture, or straightening/relaxingyour neck gives you less pain while playing.

Maybe you need larger controllers ?

Also possible the touchpads are better for fatigue than joysticks