The Ohio River is a mile wide at Louisville, but that still doesn't wide enough to classify it "large body of water", especially because it is a river that moves relatively quick for its width and then hits falls/rapids just downstream of Louisville.
But also there's a lot of urban and suburban development you'd have to displace to even consider moving the airport near the Ohio River for most miles both up and down stream of Louisville.
The Ohio River is a mile wide at Louisville, but that still doesn't wide enough to classify it "large body of water", especially because it is a river that moves relatively quick for its width and then hits falls/rapids just downstream of Louisville.
But also there's a lot of urban and suburban development you'd have to displace to even consider moving the airport near the Ohio River for most miles both up and down stream of Louisville.