Comment by bombcar
That's the biggest, the weight gone entirely unbalances the plane; if you knew exactly what happened you MIGHT be able to keep it level (and it seems they did for a bit) but eventually airspeed drops, it tips, and cartwheels (which is apparently what it did from the videos).
Deadweight or no-weight engine is a relatively negligible problem in terms of the weight-balance envelope.
Cut fuel & hydraulic lines near that engine (that affect the other engines/ apus) (or less likely structural or aerodynamic problems) is what's going to shift this from "engine failure" recoverable problem to a global nonrecoverable one.