Comment by o11c
Off the top of my head: stream count is static (an extension exists nowadays, but it's still usually unsupported), startup requires requires excessive round trips, and it's unfixably insecure (TCP actually shares this last flaw - you can only detect, not discard, injected packets - and this causes massive reliability problems in the real world). Some of the default tools were also horribly flawed even by 1990s standards (e.g. a shell script which uses $* instead of $@) last I checked.
Certainly there are things that could be done to improve the ecosystem - but why bother when you can just use a reliability layer on top of UDP instead? And these days there's a "standard" solution so you don't even need to compare choices or worry about design flaws affecting just your program: just use QUIC, everybody uses it and if something goes wrong the world will scream and the shared library will be upgraded by the distro.