Comment by MezzoDelCammin

personally : proxmox /VM is great if You'd like to separate physical HW. In my case - virtualized TrueNAS means I can give it a whole SATA controller and keep this as an isolated storage machine.

Whatever uses that storage usually runs in a Docker inside an LXC container.

If I need something more isolated (think public facing cloudflare) - that's a separate docker in another network routed through another OPNSense VM.

Desktop - VM where I passed down a whole GPU and a USB hub.

Best part - it all runs on a fairly low power HW (<20W idle NAS plus whatever the harddrives take - generally ~5W / HDD).