Comment by baxuz
It's not all about the interaction, but also the visual representation which can be much finer and granular in small spaces with a knob.
I can make a 16x16px knob where you can see almost the entire 320° of the range.
It's also easier to see fractions, such as 1/2, 1/3 or 1/4.
Sliders, especially in 16px possess none of those.