Comment by omnimus
This is a bit outdated i run mixed multi monitor setup and for last year or two it has been working no issues. Linux moves slowly but steadily and things eventualy get pretty great (another example sound and pipewire).
I think people make mistake of trying Ubuntu LTS thats super conservative with updates so you are years behind. For desktop you really want Fedora or something even more up to date. I think people sould try Fedora silverblue or its derivatives (bazzite, bluefin) its “atomic” distros that cannot be easily broken (steamos does the same).
I have tried this a year or two ago, with something that was not LTS. I was using KDE though, maybe GNOME is a bit less broken in that regard (but is in others).