True, although the i2c controller that the dimms are connected to is an entirely separate device from the i2c controller in the gpu that's connected to the display ports. As long as you know what you're doing the risk is not significant.
Makes me think of this anecdote from Linus Torvalds' officemate, from (1)
> At one point, Linus had implemented device files in /dev, and wanted to dial up the university computer and debug his terminal emulation code again. So he starts his terminal emulator program and tells it to use /dev/hda. That should have been /dev/ttyS1. Oops. Now his master boot record started with "ATDT" and the university modem pool phone number. I think he implemented permission checking the following day.
Yeah, if you are 100% confident you're using your GPU's I2C controller it's probably fine, but the reason I warned about it repeatedly in the post was because I stumbled upon this GitHub issue where two people accidentally flashed their RAM SPD:
https://github.com/bulletmark/edid-rw/issues/5