Comment by coderatlarge

“In March, the journal Nature published the discoveries of two paradigm-breaking antimicrobial compounds in as many weeks: a polyene macrolide antifungal called mandimycin and a lasso peptide antibiotic called lariocidin. Both these compounds, which use never-before-seen antimicrobial mechanisms, were found using techniques that let researchers look deep into the chemical diversity of microbes—much deeper than a typical antibiotic or antifungal screen might go.”