Comment by InitialBP

https://news.ycombinator.com/item?id=44259556

I posted another comment explaining why 1Password Vault with both a password and a OTP code is still secure, but in short it does not defeat the purpose. Your vault's are protected and in the situation where someone gets access to your vault it's most likely to be full access to your computer at which point they have other viable methods to get access to a specific service you use.