Comment by aquafox

I had similar issues in the past. Setting up renv, everything seems good, but after working in a project for a few weeks and installing packages, renv constantly complains about the library being out-of-sync and resolving these complaints took way longer than new ones came around. I think renv has good intentions, but there are just too many edge cases (Bioconductor, installing an experimental package from Github, weird package dependencies etc.), that it always failed me in a real-world scenario.