Comment by lukaszkorecki

It's doable but you need a lot, and I mean a lot of documentation proving that you are indeed an alien with extraordinary ability. Any press mentions of you and your company, articles, proof that you're working with known companies in the US and more evidence like that will increase your chance.

In fact I worked with Peter on obtaining an O1 while not having a degree, I was a CTO of a startup, moving from the UK.