Comment by hinkley

Comment by hinkley a day ago

8 replies

Oh I know we are trying to genomically test them for oncology research and potential treatment plans, but do they do paternity tests on them?

I was trying to remember which mammal in Australia gets tumors from fighting, and I found a reference to a mother getting melanoma from her daughter. It’s unclear to me whether the cancer transmission was rare or the identification is rare.

rflrob a day ago

There’s very often a comparison to the somatic (i.e. non-cancer) genome of the same patient. It’s a great way to quality control that there wasn’t some sample mixup in the lab.

Transmission of cancer is rare in humans—if it were not, it would make someone’s career to find many cases of it. While we can’t say that all sheep are white, we’ve looked at enough of them to say that black sheep are not common. Furthermore, it’s very clear how the Tasmanian devil cancer is spread—it’s around the mouth while they are biting each others faces; it’s not as obvious how one would spread most human cancers.

  • Kalanos 2 hours ago

    somatic = cancer. germline = inherited.

  • hinkley 21 hours ago

    Oh that makes sense. I forgot about differential analysis.

  • jjtheblunt 21 hours ago

    Is HPV an example?

    • cogman10 21 hours ago

      Not really. It's a virus that can cause cancer and not the cancer itself.