Comment by mannyv

One of the mechanisms of operation is to reduce your desire to eat.

Taking a step back, obesity actually is an adaptation. When food is scarce, you want your body to extract and store every gram of nutrition it can get. And that would provide a distinct advantage when you're trying to reproduce.

The thing is, GLPs don't only suppress eating. There are plenty of substances out there that can do that...and there are plenty of people who can't lose weight by starving themselves, because your body will try to maintain its weight.

The question should be "why isn't everyone obese, given the huge amount of calories available to humans?"