Comment by wat10000
This might be one of those components where it just needs to be built without problems, and improved safety means fixing individual design and manufacturing flaws as you find them, until you’ve hopefully got them all.
This can work. Fundamental structural components of airliners just can’t fail without killing everyone, and high reliability is achieved with careful design, manufacturing, testing, and inspection. I’m not sure if a gigantic non-leaky tank is harder to pull off that way, but they might have to regardless.
We’re going to have to accept that space travel is going to be inherently dangerous for the foreseeable future. Starship is in a good position to improve this, because it should fly frequently (more opportunities to discover and fix problems) and the non-manned variant is very similar to the manned variant (you can discover many problems without killing people). But there are inherent limitations. There’s just not as much capacity for redundancy. The engines have to be clustered so fratricide or common failure modes are going to me more likely. Losing all the engines is guaranteed death on Starship, versus a good chance to survive in an airliner.
All other practical considerations aside, I think this alone sinks any possibility of using Starship for Earth-to-Earth travel as has been proposed by SpaceX.
High reliability of airliners is achieved by having redundancy of all critical parts. The idea is no single failure can cause a crash.
For example, if system A has a failure probability of 10%, if A is redundant with another A', the combined failure probability is 1%.
That of course presumes that A and A' are not connected.