Comment by mxfh
Desaturation methods are tricky as well. So is the image information transformation on it's way to the hardware and display hardware characteristics themselves.
Accurate color reproduction on uncalibrated consumer devices is just wishful thinking and will not be fixed in the forseeable future.
So unless you work in a color controlled and calibrated environment it's hard to make any reliable statements about perception.
I simply would not worry too much about optimizing perceptual color spaces at this point.