Comment by KronisLV
Curiously, even Apache2 has functionality in the form of mod_md: https://httpd.apache.org/docs/2.4/mod/mod_md.html
Not as advanced as in Caddy (which will be a more pleasant option to use in many cases), but it's curious to see them adding something like that! Makes me wonder whether we'll also get some Nginx functionality like that out of the box sometime so certbot won't have to always be installed alongside it for sites that need to use ACME.