Comment by dandanua

Desktop NixOS is my daily driver for almost 3 years. I don't bother diving into deep technicalities, flakes or other complicated stuff. I define programs and settings that I need in the configuration.nix. That's all. And it works perfectly!

For complicated stuff I run containers such as docker or podman (you could use distrobox too), so I don't have a headache while trying to achieve it in NixOS (but I respect everyone who does this and makes this system grow).