Comment by rgbswan
Combo of tricyclic antidepressant and amphetamines "turned me gayer and gayer" (and gave me the shitters) which reversed a few weeks after I stopped them. My Testosterone was stable throughout those months.
And I just remembered a girl I studied with whose ex-boyfriends turned gay or bisexual post-relationship. Pretty sure it was her gut bacteria.
Completely anecdotal, but I recently did a round of oral antibiotics and afterwards followed up with an expensive probiotic.
It was like $60 a bottle for a 1 month supply, but I was told that oral antibiotics can wreck your gut biome so I figured this was the ideal time to repair/replace the biome I have.
In the 6 weeks since then I've lost ~30 lbs (I am following a diet, of course, this has been wildly successful but intentional in the abstract) and I have more energy, sleep better, and have lost my baseline "snack late at night" urges. Physiologically I do not feel deprived of food, hungry, or tired all the time like I have with previous diets. I've also cut my caffeine intake to almost 1/3rd of its previous amount and I drink more water.
I am sure there's a lot going on beside that, so I am not blaming my progress on the 1 thing by itself, but that being said, it does seem highly coincidental and correlated.
Might be worth a deeper dive, blow out (mostly) healthy people's gut bacteria, replace it with very specific blends, accumulate the data on what changes happen or what people report happening in the 2 weeks, 6 weeks, 3 months, 6 months 1 year afterward.