Comment by cwillu
Nothing specific to the RT scheduler that I've noticed; there is a constant overhead from the audio stuff, but that's because of the workload (enabled by RT), not because of the RT itself.
My usual setup has 2 PianoTeq (physically modelled piano/electric piano/clavinet) instances, 3 SurgeXT instances (standard synthesizer), a setBfree (Tonewheel/hammond simulator) instance, and a handful of sequencers and similar for drums, as well as a bunch of routing and compressors and such.