Comment by gamblor956

All of those other oral probiotics are based on published research about naturally occurring bacterial strains already present in the environment, and in some cases have the evidentiary support of human trials.

Lumina is a genetically modified bacteria. It has no research supporting its effectiveness because the original inventors never bothered to conduct a human trial; they just said that it probably works based on testing in a petri dish. (Note: lots of drugs work in petri dishes and laboratory animals. Very few go on to have success in humans.)

Notably, the founder of the current company selling it has does not have a background in dentistry or microbiology and does not understand how his company's product actually works.