Comment by wtallis
> 1x 8 GB DIMM is a lot easier to drive than 4x 48 for example.
That's a bit of an exaggeration. What matters are DIMMs per channel, and ranks per DIMM. Consumer systems have at most two memory slots per channel, so 2x 8GB modules installed correctly is just two separate instances of one DIMM per channel, and 4x48GB is two separate instances of two DIMMs per channel, with each module being dual-rank.
The best configurations for overclocking are supposed to be motherboards with only one memory slot per channel, so that when operating with one DIMM per channel there are no empty slots providing stubs of wiring that degrade signal integrity. But very few motherboards restrict themselves like this for the sake of memory overclocking.
4x 8 GB is still a lot easier to drive at high speed than 4x 48 GB, but yes, one factor in the above comparison is indeed the number of DIMMs per channel. Ranks per DIMM is definitely a factor as well, though on large capacity DIMMs that tends to be a one sided story. Another factor in the rabbit hole is banks, tying it all back.
The other part of 2 DIMM boards is the trace lengths can be that much shorter (they need to be the same length so fewer slots means less max length to match to).